In this project, two newly developed refrigerants, R1234yf and R1234ze have been studied as promising drop-in replacements for the common high global warming potential refrigerants. In view of that, thermodynamic and transport properties of new refrigerants were obtained by RefProp version 7.01 to study and compare their cycle performances with current refrigerants. Furthermore, their environmental and safety aspects have been studied in order to predict probable risks and suitable preparations in different applications. Basic cycle data of both new refrigerants have been calculated for most commonly used condensing and evaporating temperatures. According to evaluation of these tables, both refrigerants generally have comparable COP and volumetric cooling capacity with R134a for an isentropic compression.